The harrowing incident took place around 11:10 p.m. as the driver of the Bx35 bus was trying to turn left off University Avenue onto a ramp to the Washington Bridge, according to MTA sources.
But the male driver veered off track, causing the bus to crash off the elevated road.
The front section of the bus landed flat on its windshield on the Cross Bronx Expressway, while the rear portion remained grounded on University Avenue.
One of the victims sustained serious injuries, the FDNY said, while the others’ injuries were considered non-life-threatening and minor.
Witness Bryan Garcia said he was in his apartment when he saw the bus run off the road.
Then he said, “I heard a big boom, a crash. I heard people from the bus screaming for help.”
Once Garcia got outside, he said, first responders were already rescuing people from the bus.
It was not immediately clear if all the injuries were sustained by people aboard the bus.
The victims were all taken to area hospitals, the FDNY said.